Lectures (Video)
- 1. How Do You Know?
- 2. Force Laws, Lewis Structures and Resonance
- 3. Double Minima, Earnshaw's Theorem and Plum-Puddings
- 4. Coping with Smallness and Scanning Probe Microscopy
- 5. X-Ray Diffraction
- 6. Seeing Bonds by Electron Difference Density
- 7. Quantum Mechanical Kinetic Energy
- 8. One-Dimensional Wave Functions
- 9. Chladni Figures and One-Electron Atoms
- 10. Reality and the Orbital Approximation
- 11. Orbital Correction and Plum-Pudding Molecules
- 12. Overlap and Atom-Pair Bonds
- 13. Overlap and Energy-Match
- 14. Checking Hybridization Theory with XH3
- 15. Chemical Reactivity: SOMO, HOMO, and LUMO
- 16. Recognizing Functional Groups
- 17. Reaction Analogies and Carbonyl Reactivity
- 18. Amide, Carboxylic Acid and Alkyl Lithium
- 19. Oxygen and the Chemical Revolution (Beginning to 1789)
- 20. Rise of the Atomic Theory (1790-1805)
- 21. Berzelius to Liebig and Wöhler (1805-1832)
- 22. Radical and Type Theories (1832-1850)
- 23. Valence Theory and Constitutional Structure (1858)
- 24. Determining Chemical Structure by Isomer Counting (1869)
- 25. Models in 3D Space (1869-1877); Optical Isomers
- 26. Van't Hoff's Tetrahedral Carbon and Chirality
- 27. Communicating Molecular Structure in Diagrams and Words
- 28. Stereochemical Nomenclature; Racemization and Resolution
- 29. Preparing Single Enantiomers and the Mechanism of Optical Rotation
- 30. Esomeprazole as an Example of Drug Testing and Usage
- 31. Preparing Single Enantiomers and Conformational Energy
- 32. Stereotopicity and Baeyer Strain Theory
- 33. Conformational Energy and Molecular Mechanics
- 34. Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes
- 35. Understanding Molecular Structure and Energy through Standard Bonds
- 36. Bond Energies, the Boltzmann Factor and Entropy
- 37. Potential Energy Surfaces, Transition State Theory
Introductory Organic Chemistry - Lecture 29
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Lecture 29 - Preparing Single Enantiomers and the Mechanism of Optical Rotation
Within a lecture on biological resolution, the synthesis of single enantiomers, and the naming and 3D visualization of omeprazole, Professor Laurence Barron of the University of Glasgow delivers a guest lecture on the subject of how chiral molecules rotate polarized light. Mixing wave functions by coordinated application of light's perpendicular electric and magnetic fields shifts electrons along a helix that can be right- or left-handed, but so many mixings are involved, and their magnitudes are so subtle, that predicting net optical rotation in practical cases is rarely simple.
Prof. J. Michael McBride
CHEM 125: Freshman Organic Chemistry, Fall 2008 (Yale University: Open Yale) http://oyc.yale.edu Date accessed: 2009-11-11 License: Creative Commons BY-NC-SA |
Lecture Material
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